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Technical Data
| Formula | C20H24N2O5S |
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| Molecular Weight | 404.48 | CAS No. | 210826-40-7 | |
| Solubility (25°C)* | In vitro | DMSO | 81 mg/mL (200.25 mM) | |
| Ethanol | 3 mg/mL (7.41 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. | ||||
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| Targets |
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| In vitro | MCC950 specifically inhibits NLPR3 inflammasome activation.[1] |
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| In vivo | Inhibition of NLRP3 with MCC950 ameliorates proteinuria, renal histological lesions and podocyte foot process effacement in lupus-prone mice.[1] |
Biological Activity
| Description | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. | ||||
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| Targets |
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Protocol (from reference)
Selleck's MCC950 has been cited by 110 publications
| METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner [ Cell Death Dis, 2024, 15(1):43] | PubMed: 38218935 |
| Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome [ Cell Prolif, 2024, e13720.] | PubMed: 39045886 |
| Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway [ J Transl Med, 2024, 22(1):497] | PubMed: 38796413 |
| ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke [ J Transl Med, 2024, 22(1):23] | PubMed: 38178174 |
| Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner [ Cell Death Discov, 2024, 10(1):122] | PubMed: 38458999 |
| Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats [ Transl Psychiatry, 2024, 14(1):166] | PubMed: 38538614 |
| From inflammation to pyroptosis: Understanding the consequences of cadmium exposure in chicken liver cells [ Ecotoxicol Environ Saf, 2024, 272:116004] | PubMed: 38290315 |
| Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids [ Immunology, 2024, 10.1111/imm.13773] | PubMed: 38468451 |
| GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury [ Am J Pathol, 2024, S0002-9440(24)00116-0] | PubMed: 38548270 |
| NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis [ Int J Mol Med, 2024, 53(3)25] | PubMed: 38240085 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.