MCC950

Catalog No.S8930 Batch:S893001

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Technical Data

Formula

C20H24N2O5S
Molecular Weight 404.48 CAS No. 210826-40-7
Solubility (25°C)* In vitro DMSO 81 mg/mL (200.25 mM)
Ethanol 3 mg/mL (7.41 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Targets
NLRP3 [1]
(BMDM-based assay)		 NLRP3 [1]
(HMDM-based assay)
7.5 nM 8.1 nM

Biological Activity

Description MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Targets
NLRP3 [1]
(BMDM-based assay)		 NLRP3 [1]
(HMDM-based assay)
7.5 nM 8.1 nM
In vitro

MCC950 specifically inhibits NLPR3 inflammasome activation.[1]
In vivo

Inhibition of NLRP3 with MCC950 ameliorates proteinuria, renal histological lesions and podocyte foot process effacement in lupus-prone mice.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    NZM2328 podocyte cell line

  • Concentrations

    1 µM

  • Incubation Time

    24 h

  • Method

    The NZM2328 podocyte cell line was stimulated with a control serum or a serum from diseased NZM2328 mice or serum from diseased NZM2328 mice depleted of IgG, with or without MCC950 or Mito TEMPO for 24 hours. After this incubation, cells were subjected to flow cytometry and Western blot analyses for NLRP3 inflammasome activation, mitochondrial membrane potential and production of reactive oxygen species (ROS) analysis.

    (Data sourced from selleck products)
Animal Study:

[1]
  • Animal Models

    female NZM2328, a new NZM strain produced by extended backcrosses of NZB/WF1 to NZW mice

  • Dosages

    10mg/kg

  • Administration

    i.p.

    (Data sourced from selleck products)

Selleck's MCC950 has been cited by 116 publications

Breast cancer-derived CAV1 promotes lung metastasis by regulating integrin α6β4 and the recruitment and polarization of tumor-associated neutrophils [ Int J Biol Sci, 2024, 20(14):5695-5714] PubMed: 39494337
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner [ Cell Death Dis, 2024, 15(1):43] PubMed: 38218935
Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome [ Cell Prolif, 2024, e13720.] PubMed: 39045886
Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells [ J Transl Med, 2024, 22(1):1139] PubMed: 39716284
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation [ J Transl Med, 2024, 22(1):954] PubMed: 39434134
Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway [ J Transl Med, 2024, 22(1):497] PubMed: 38796413
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke [ J Transl Med, 2024, 22(1):23] PubMed: 38178174
Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner [ Cell Death Discov, 2024, 10(1):122] PubMed: 38458999
Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats [ Transl Psychiatry, 2024, 14(1):166] PubMed: 38538614
From inflammation to pyroptosis: Understanding the consequences of cadmium exposure in chicken liver cells [ Ecotoxicol Environ Saf, 2024, 272:116004] PubMed: 38290315

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.