MC180295

Catalog No.S8809 Batch:S880902

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Technical Data

Formula

C17H18N4O3S
Molecular Weight 358.41 CAS No. 2237942-08-2
Solubility (25°C)* In vitro DMSO 72 mg/mL (200.88 mM)
Ethanol 72 mg/mL (200.88 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.
Targets
CDK9-Cyclin T1 [1]
(Cell-free assay)		 CDK4-Cyclin D [1]
(Cell-free assay)		 CDK1-Cyclin B [1]
(Cell-free assay)		 CDK5-P35 [1]
(Cell-free assay)		 CDK5-P25 [1]
(Cell-free assay)		 View More
5 nM 112 nM 138 nM 159 nM 186 nM
In vitro

MC180295 has broad anti-cancer activity in vitro[1].
In vivo

MC180295 shows promising anti-tumoral and immunosensitization activity[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Normal lung fibroblast (IMR90) and cancer cell lines (HCT116, KG-1, HL-60, SW48, MCF7, DU145 and LnCaP)

  • Concentrations

    0.1 μM

  • Incubation Time

    4 days

  • Method

    --
Animal Study:

[1]
  • Animal Models

    NSG mice

  • Dosages

    5-20mg/kg

  • Administration

    IP

Selleck's MC180295 has been cited by 1 publication

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle [ Int J Mol Sci, 2022, 23(18)10597] PubMed: 36142506

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.