Manganese chloride

Catalog No.S4827 Batch:S482701

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Technical Data

Formula

MnCl2
Molecular Weight 125.84 CAS No. 7773-01-5
Solubility (25°C)* In vitro Water 100 mg/mL (794.65 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.
In vitro MnCl2 inhibits proliferation in a dose- and time-dependent manner, induces G0/G1 and S phase arrest and apoptosis in A549 cells[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    A549 cells

  • Concentrations

    0.1, 0.5, 1.0 or 2.0 mM

  • Incubation Time

    24, 48 or 72 h

  • Method

    Cells are treated with various concentrations of MnCl2 (0, 0.01, 0.1, 0.5, 1.0 or 2.0 mM) for 24, 48 or 72 h. Cell proliferation is determined with MTT assay and mitotic index measurement and apoptosis is measured by flow cytometer.
Animal Study:

[2]
  • Animal Models

    9-10 week old Fischer 344/N rats and FVB/N mice

  • Dosages

    2.0-2.3 mg/m3 at a flow rate of 20 L/min

  • Administration

    inhalation exposure

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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