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Formula | C28H27F4N7O3S |
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Molecular Weight | 617.62 | CAS No. | 1082949-68-5 | ||||||||
Solubility (25°C)* | In vitro | DMSO | 25 mg/mL (40.47 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1. | ||
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Targets |
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In vitro | In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2] | ||
In vivo | LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1] |
Animal Study: |
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Data from [Data independently produced by , , PLoS One, 2017, 12(1):e0169804]
Deep PIM kinase substrate profiling reveals new rational cotherapeutic strategies for acute myeloid leukemia [ Blood Adv, 2024, 8(15):3880-3892] | PubMed: 38739710 |
Nutrient-regulated control of lysosome function by signaling lipid conversion [ Cell, 2023, 186(24):5328-5346.e26] | PubMed: 37883971 |
Nutrient-regulated control of lysosome function by signaling lipid conversion [ Cell, 2023, 10.1016/j.cell.2023.09.027] | PubMed: 37883971 |
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly [ Nat Commun, 2022, 13(1):4848] | PubMed: 35977928 |
Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells [ Cancer Res, 2022, can.21.2908] | PubMed: 35792658 |
P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production [ Front Immunol, 2022, 13:821932] | PubMed: 35154140 |
Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder [ Transl Psychiatry, 2022, 12(1):184] | PubMed: 35508467 |
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells [ Cell Signal, 2022, 94:110311] | PubMed: 35306137 |
Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells [ PLoS Comput Biol, 2021, 17(6):e1009125] | PubMed: 34191793 |
Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASMUT melanoma [ bioRxiv, 2021, 10.1101/2021.04.07.438684] | PubMed: none |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.