LY2584702

Catalog No.S7698 Batch:S769802

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Technical Data

Formula

C21H19F4N7
Molecular Weight 445.42 CAS No. 1082949-67-4
Solubility (25°C)* In vitro DMSO 15 mg/mL (33.67 mM)
Water ˂1 mg/mL
Ethanol ˂1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.
Targets
p70S6K [1]
4 nM
In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1]

LY2584702 has significant synergistic effects when combined with EGFR inhibitor or with the mTOR inhibitor. [2]
In vivo

LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    Neuronal cells

  • Concentrations

    250 nM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentration of drug for 24 h.
Animal Study:

[1]
  • Animal Models

    U87MG glioblastoma and HCT116 colon carcinoma xenograft models

  • Dosages

    12.5 mg/kg BID

  • Administration

    --

Customer Product Validation

Data from [Data independently produced by , , Oncotarget, 2016, 7(25):38451-38466]

Data from [Data independently produced by , , J Immunol, 2016, 197(9):3545-3553]

Data from [Data independently produced by , , Antiviral Res, 2018, 158:13-24]

Data from [Data independently produced by , , PLoS One, 2017, 12(1):e0169804]

Selleck's LY2584702 has been cited by 24 publications

mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes [ Mol Cell, 2024, S1097-2765(24)00832-3] PubMed: 39486419
Duloxetine enhances the sensitivity of non-small cell lung cancer cells to EGFR inhibitors by REDD1-induced mTORC1/S6K1 suppression [ Am J Cancer Res, 2024, 14(3):1087-1100] PubMed: 38590408
Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage [ ACS Bio Med Chem Au, 2023, 3(3):283-294] PubMed: 37363079
Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage [ ACS Bio Med Chem Au, 2023, 3(3):283-294] PubMed: 37363079
Control of cell state transitions [ Nature, 2022, 609(7929):975-985] PubMed: 36104561
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly [ Nat Commun, 2022, 13(1):4848] PubMed: 35977928
Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells [ Cancer Res, 2022, can.21.2908] PubMed: 35792658
P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production [ Front Immunol, 2022, 13:821932] PubMed: 35154140
Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder [ Transl Psychiatry, 2022, 12(1):184] PubMed: 35508467
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells [ Cell Signal, 2022, 94:110311] PubMed: 35306137

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.