LY-3475070

Catalog No.S9867 Batch:S986701

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Technical Data

Formula

C15H18N4O2
Molecular Weight 286.33 CAS No. 2375815-63-5
Solubility (25°C)* In vitro DMSO 57 mg/mL (199.07 mM)
Ethanol 10 mg/mL (34.92 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
8%DMSO 92%Corn oil
2.0mg/ml Taking the 1 mL working solution as an example, add 80 μL of 25 mg/ml clear DMSO stock solution to 920 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).
Targets
CD73 [1]
In vitro

LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    PBMCs

  • Concentrations

    1 μM

  • Incubation Time

    2 h

  • Method

    Cells were treated with indicated concentration of drug for 2 h.

Selleck's LY-3475070 has been cited by 2 publications

Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment [ Theranostics, 2024, 14(3):1224-1240] PubMed: 38323313
CD39 pathway inhibits Th1 cell function in tuberculosis [ Immunology, 2022, 10.1111/imm.13493] PubMed: 35574713

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.