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Technical Data
| Formula | C22H23F3N8O |
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| Molecular Weight | 472.47 | CAS No. | 1874276-76-2 | |
| Solubility (25°C)* | In vitro | DMSO | 60 mg/mL (126.99 mM) | |
| Ethanol | 20 mg/mL (42.33 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC). | |
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| In vitro | LXS-196 (Darovasertib) is a highly specific PKC inhibitor that resulted in a concentration dependent inhibition of immunoprecipitated LRRK1 kinase activity, with an IC50 of ∼40 nM. |
Protocol (from reference)
| Cell Assay: |
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References
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Selleck's Darovasertib (LXS-196) has been cited by 4 publications
| High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma [ Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101244] | PubMed: 37858338 |
| Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation [ Cell Mol Biol Lett, 2023, 28(1):24] | PubMed: 36959535 |
| Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion [ Commun Biol, 2022, 5(1):795] | PubMed: 35941177 |
| PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain [ Biochem J, 2022, 479(18):1941-1965] | PubMed: 36040231 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.