Darovasertib (LXS-196)

Catalog No.S6723 Batch:S672301

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Technical Data

Formula

C22H23F3N8O

Molecular Weight 472.47 CAS No. 1874276-76-2
Solubility (25°C)* In vitro DMSO 22 mg/mL (46.56 mM)
Ethanol 6 mg/mL (12.69 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).
Targets
PKC [1]
In vitro

LXS-196 (Darovasertib) is a highly specific PKC inhibitor that resulted in a concentration dependent inhibition of immunoprecipitated LRRK1 kinase activity, with an IC50 of ∼40 nM.

Protocol (from reference)

Cell Assay:

[2]

  • Cell lines

    HEK293 cells

  • Concentrations

    ∼40 nM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentration of the drug for 24 hour.

Selleck's Darovasertib (LXS-196) has been cited by 4 publications

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma [ Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101244] PubMed: 37858338
Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation [ Cell Mol Biol Lett, 2023, 28(1):24] PubMed: 36959535
Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion [ Commun Biol, 2022, 5(1):795] PubMed: 35941177
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain [ Biochem J, 2022, 479(18):1941-1965] PubMed: 36040231

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.