LM11A-31

Catalog No.S9848 Batch:S984801

Technical Data

Formula	C₁₂H₂₅N₃O₂
Molecular Weight	243.35	CAS No.	289475-77-0
Solubility (25°C)*	In vitro	DMSO	49 mg/mL (201.35 mM)
		Water	49 mg/mL (201.35 mM)
		Ethanol	49 mg/mL (201.35 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	LM11A-31 is a small molecule p75^NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.
In vitro	LM11A-31 greatly reduces or eliminates the neuronal pathology as well as the FIV effects on astrocytes and microglia in an infectious in vitro model, indicating an excellent potential for the treatment of HIV-associated neurodegeneration.<sup><a class="sref" href="#s_ref">[1]</a></sup>
In vivo	LM11A-31 is a small molecular p75<sup>NTR</sup> ligand, which reverses cholinergic neurite dystrophy in mice with advanced Alzheimer's disease.<sup><a class="sref" href="#s_ref">[2]</a></sup>

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines Feline choroid plexus macrophages infected with FIV Concentrations 10 nM Incubation Time 14 h Method Cat neurons were seeded at a very low density and half the cultures were treated with 10 nM LM11A-31 in the medium. Initial seeding density was matched within each run at approximately 2,800-4,000 cells/cm2 and cultures were fed every 2 days with complete MEM or MEM + LM11A-31.
Animal Study:^{<sup><a class="sref" href="#s_ref">[2]</a></sup>}	Animal Models Thy-1 hAPP^Lond/Swe (APP^L/S) and Tg2576 mouse model Dosages 50 mg/kg for APP^L/S mouse; 10, 50, 75 and 100 mg/kg/day (n=3-4 Tg2576 mice/dose) Administration Oral gavage

Cell Assay:^{^[1]}

Cell lines
Feline choroid plexus macrophages infected with FIV
Concentrations
10 nM
Incubation Time
14 h
Method
Cat neurons were seeded at a very low density and half the cultures were treated with 10 nM LM11A-31 in the medium. Initial seeding density was matched within each run at approximately 2,800-4,000 cells/cm2 and cultures were fed every 2 days with complete MEM or MEM + LM11A-31.

Animal Study:^{<sup><a class="sref" href="#s_ref">[2]</a></sup>}

Animal Models
Thy-1 hAPP^Lond/Swe (APP^L/S) and Tg2576 mouse model
Dosages
50 mg/kg for APP^L/S mouse; 10, 50, 75 and 100 mg/kg/day (n=3-4 Tg2576 mice/dose)
Administration
Oral gavage

References

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SHIPPING AND STORAGE
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