LL37 (Human cathelicidin)

Catalog No.P1201 Batch:P120101

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Technical Data

Formula

C205H340N60O53
Molecular Weight 4493.26 CAS No. 154947-66-7
Solubility (25°C)* In vitro Water 50 mg/mL (11.12 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.
In vitro

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing
Density 95.0~105.0%

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    HCECs

  • Concentrations

    1, 2.5, 5, 10 and 20 μg/mL

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentrations of drug for 24 h.
Animal Study:

[3]
  • Animal Models

    6-8 week-old C57BL/6 mice with MRSA-induced pneumonia

  • Dosages

    0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg

  • Administration

    i.t.

Selleck's LL37 (Human cathelicidin) has been cited by 2 publications

Dietary supplementation of n-3 PUFAs ameliorates LL37-induced rosacea-like skin inflammation via inhibition of TLR2/MyD88/NF-κB pathway [ Biomed Pharmacother, 2023, 157:114091] PubMed: 36481403
Celastrol inhibits LL37-induced rosacea by inhibiting Ca2+/CaMKII-mTOR-NF-κB activation [ Biomed Pharmacother, 2022, 153:113292] PubMed: 35717785

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.