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Formula | C172H265N43O51 |
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Molecular Weight | 3751.25 | CAS No. | 204656-20-2 | ||||
Solubility (25°C)* | In vitro | Water | 100 mg/mL (26.65 mM) | ||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist. | |
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Targets |
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In vitro | Liraglutide attenuates induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression in human vascular endothelial cells (hVECs) in vitro and may afford protection against endothelial cell dysfunction (ECD), an early abnormality in diabetic vascular disease. In vitro studies demonstrates GLP-1R-dependent liraglutide-mediated inhibition of stimulated PAI-1 and VAM expression[3]. |
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In vivo | In vivo studies of vascular reactivity and immunohistochemical analysis are performed in the ApoE-/- mouse model. They demonstrate significant improvement in endothelial function in liraglutide treated mice, a GLP-1R dependent effect. Liraglutide treatment also increases endothelial nitric oxide synthase (eNOS) and reduces intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium, an effect again dependent on the GLP-1R[3]. Liraglutide reduces hyperglycemia in T2D mouse models by increasing pancreatic b cell mass through enhanced proliferation[2]. |
Cell Assay: |
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Animal Study: |
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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy [ J Immunother Cancer, 2024, 12(3)e008431] | PubMed: 38458640 |
Hypertonicity during a rapid rise in D-glucose mediates first-phase insulin secretion [ Front Endocrinol (Lausanne), 2024, 15:1395028] | PubMed: 38989001 |
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight [ Mol Metab, 2023, 76:101794] | PubMed: 37604246 |
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight [ Mol Metab, 2023, 76:101794] | PubMed: 37604246 |
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells [ Cell Rep Methods, 2023, 3(11):100642] | PubMed: 37963464 |
Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety [ bioRxiv, 2023, 10.1101/2023.10.31.564990] | PubMed: 37961449 |
Dietary resistant starch ameliorating lipopolysaccharide-induced inflammation in meat ducks associated with the alteration in gut microbiome and glucagon-like peptide 1 signaling [ J Anim Sci Biotechnol, 2022, 13(1):91] | PubMed: 35836245 |
Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial cells [ Life Sci, 2022, 292:120331] | PubMed: 35041837 |
Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants [ Biosensors (Basel), 2022, 13(1)48] | PubMed: 36671883 |
Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants [ Biosensors (Basel), 2022, 13(1)48] | PubMed: 36671883 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.