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Formula | C19H21ClN4 |
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Molecular Weight | 340.85 | CAS No. | 950455-15-9 | |
Solubility (25°C)* | In vitro | DMSO | Insoluble | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. | ||
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In vitro | Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).[1] | ||
In vivo | Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. [1] |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Mol Psychiatry, 2017, 22(11):1520-1530]
Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]
Data from [Data independently produced by , , Redox Biol, 2017, 12:8-17]
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism [ Nat Commun, 2025, 16(1):509] | PubMed: 39779666 |
A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation [ Neuron, 2025, S0896-6273(25)00136-9] | PubMed: 40101721 |
Inhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation [ Adv Sci (Weinh), 2025, 12(7):e2408789] | PubMed: 39739602 |
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation [ EMBO J, 2025, 10.1038/s44318-025-00369-5] | PubMed: 39881208 |
Upregulated FSP1 by GPD1/1L mediated lipid droplet accumulation enhances ferroptosis resistance and peritoneal metastasis in gastric cancer [ Cell Commun Signal, 2025, 23(1):132] | PubMed: 40075460 |
Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis [ J Transl Med, 2025, 23(1):206] | PubMed: 39980044 |
Lycium barbarum glycopeptide reduces brain damage following ischemic stroke by inhibiting ferroptosis and oxidation [ Neural Regen Res, 2025, 10.4103/NRR.NRR-D-24-00747] | PubMed: 39930986 |
Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells [ Transl Oncol, 2025, 52:102227] | PubMed: 39644823 |
Inhibition of Hippocampal Neuronal Ferroptosis by Liproxstatin-1 Improves Learning and Memory Function in Aged Mice with Perioperative Neurocognitive Dysfunction [ J Inflamm Res, 2025, 18:2991-3007] | PubMed: 40046685 |
Involvement of STAT3 activation in ameliorating all-trans-retinal-induced ferroptosis in photoreceptor-derived 661W cells in vitro [ Exp Eye Res, 2025, 253:110280] | PubMed: 39947311 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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