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Technical Data
| Formula | C29H28F4N4O4 |
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| Molecular Weight | 572.55 | CAS No. | 917389-32-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (174.65 mM) | |
| Ethanol | 100 mg/mL (174.65 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
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| In vitro | AIC246 blocks viral replication without inhibiting the synthesis of progeny HCMV DNA or viral proteins. It is one of the most potent anti-HCMV agents reported to date, with a cell culture EC50 in the one-digit nanomolar range (∼5 nM) and a selectivity index exceeding 15,000[1]. |
| In vivo | AIC246 treatment leads to a dose-dependent reduction of the HCMV titer in transplanted cells compared to that of the placebo-treated control group using the mouse xenograft model[2]. |
Protocol (from reference)
References
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Selleck's Letermovir (AIC246) has been cited by 2 publications
| The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs [ Antiviral Res, 2021, 189:105062] | PubMed: 33722615 |
| Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture [ bioRxiv, 2020, 2020.08.12.246389] | PubMed: 32817953 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.