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Technical Data
| Formula | C9H11NO3 |
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| Molecular Weight | 181.19 | CAS No. | 60-18-4 | |
| Solubility (25°C)* | In vitro | 5%TFA | 6.02 mg/mL (33.22 mM) | |
| DMSO | 0.1 mg/mL (0.55 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | L-tyrosine ((S)-Tyrosine, P-Tyrosine, L-p-Tyrosine) is a non-essential amino acid. In animals it is synthesized from Ephenylalanine. |
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| In vitro | L-tyrosine in vitro inhibits citrate synthase activity in the posterior cortex. Succinate dehydrogenase activity is increased in the posterior cortex, hippocampus, striatum and liver. Complex I activity is inhibited in the hippocampus, complex II activity is also inhibited in the hippocampus and in the posterior cortex and liver, complex II–III activity is not altered by L-tyrosine and complex IV activity decreased in the posterior cortex[1]. |
| In vivo | Acute administration of L-tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum[1]. |
Protocol (from reference)
| Animal Study: |
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.