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Technical Data
| Formula | C9H20N4O4 |
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| Molecular Weight | 248.28 | CAS No. | 53308-83-1 | |
| Solubility (25°C)* | In vitro | Water | 50 mg/mL (201.38 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS. | ||
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| Targets |
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| In vitro | As a nitric oxide synthase inhibitor, L-NMMA acetate has the Ki values for nNOS (rat) and iNOS (rat) are approximately 0.18 and 6 µM, respectively.[3] |
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| In vivo | Following L-NMMA acetate administration, skeletal muscle contractile function is dose-dependently decreased with the administration of drug during ischemia/reperfusion (I/R) in vivo.[1] |
Protocol (from reference)
| Animal Study: |
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References
Selleck's L-NMMA acetate has been cited by 2 publications
| Intracellular osteopontin potentiates the immunosuppressive activity of mesenchymal stromal cells [ Stem Cell Res Ther, 2024, 15(1):366] | PubMed: 39407354 |
| A novel dual-channel fluorescent probe for selectively and sensitively imaging endogenous nitric oxide in living cells and zebrafish [ Spectrochim Acta A Mol Biomol Spectrosc, 2022, 277:121280] | PubMed: 35472703 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.