L-765314

Catalog No.S0862 Batch:S086201

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Technical Data

Formula

C27H34N6O5
Molecular Weight 522.60 CAS No. 189349-50-6
Solubility (25°C)* In vitro DMSO 100 mg/mL (191.35 mM)
Ethanol 100 mg/mL (191.35 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description L-765314 is a selective and potent α1b-adrenoceptor (α1b adrenergic receptor) antagonist with an IC50 of 1.90 nM and Kis of 5.4 and 2.0 for rat and human α1b adrenergic receptor, respectively.
Targets
α1b-adrenoceptor [1] α1b-adrenoceptor [1]
(in receptor binding affinity to human experiment)		 α1b-adrenoceptor [1]
(in receptor binding affinity to rat experiment)
1.9 nM 2 μM(Ki) 5.4 μM(Ki)
In vitro

L-765,314 is a potent and selective α1b adrenergic receptor antagonist, which also reduces melanin production by targeting the protein kinase C (PKC)-dependent regulation of tyrosinase activity and raises the intracellular level of melanin precursors.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Mel-ab cells

  • Concentrations

    10 µM

  • Incubation Time

    96 h

  • Method

    PKC activity is assessed in Mel-ab cells treated with L-765,314 for 96 h by immunoblotting with phospho-PKC substrate antibody.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.