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Formula | C17H11F6N7O |
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Molecular Weight | 443.31 | CAS No. | 1393477-72-9 | |
Solubility (25°C)* | In vitro | DMSO | 89 mg/mL (200.76 mM) | |
Ethanol | 22 mg/mL (49.62 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2. | |
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In vitro | As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM. [1] | |
In vivo | KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells. [1] In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs. [2] |
Cell Assay:[1] |
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Animal Study:[1] |
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, , Mol Cancer Ther, 2017, 16(4):717-728
Data from [Data independently produced by , , J Cell Mol Med, 2018, doi:10.1111/jcmm.13886]
Data from [Data independently produced by , , BMC Cancer, 2018, 18(1):764]
Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(3):1773-1779]
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3] | PubMed: 38262581 |
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome [ Nat Cell Biol, 2024, 10.1038/s41556-023-01338-y] | PubMed: 38267537 |
Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage [ Nat Commun, 2024, 15(1):2859] | PubMed: 38570500 |
Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation [ Nat Commun, 2024, 15(1):1231] | PubMed: 38336745 |
UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas [ Cell Rep Med, 2024, S2666-3791(23)00610-9] | PubMed: 38244540 |
A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma [ J Exp Clin Cancer Res, 2024, 43(1):148] | PubMed: 38773631 |
A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma [ J Exp Clin Cancer Res, 2024, 43(1):148] | PubMed: 38773631 |
A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer [ Cell Death Dis, 2024, 15(8):638] | PubMed: 39217152 |
Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib [ Cell Death Dis, 2024, 15(8):588] | PubMed: 39138149 |
Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer [ Cell Rep, 2024, 43(11):114916] | PubMed: 39475510 |
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Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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