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Technical Data
| Formula | C24H26F3N7O2 |
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| Molecular Weight | 501.50 | CAS No. | 853299-07-7 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (199.4 mM) | |
| Ethanol | 15 mg/mL (29.91 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | K03861 (AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. | ||||||||
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| Targets |
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| In vitro | K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1] |
Protocol (from reference)
Selleck's K03861 (AUZ454) has been cited by 15 publications
| Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia [ Microbiol Spectr, 2023, 11(2):e0491922] | PubMed: 36877015 |
| Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia [ Microbiol Spectr, 2023, 11(2):e0491922] | PubMed: 36877015 |
| Genetic instability from a single S phase after whole-genome duplication [ Nature, 2022, 604(7904):146-151] | PubMed: 35355016 |
| p53 directs leader cell behavior, migration, and clearance during epithelial repair [ Science, 2022, 375(6581):eabl8876] | PubMed: 35143293 |
| Icaritin inhibits CDK2 expression and activity to interfere with tumor progression [ iScience, 2022, 25(9):104991] | PubMed: 36093042 |
| Comprehensive drug response profiling and pan-omic analysis identified therapeutic candidates and prognostic biomarkers for Asian cholangiocarcinoma [ iScience, 2022, 25(10):105182] | PubMed: 36248745 |
| Transient inhibition of CDK2 activity prevents oocyte meiosis I completion and egg activation in mouse [ J Cell Physiol, 2022, 10.1002/jcp.30885] | PubMed: 36161883 |
| Postnatal expression and possible function of RANK and RANKL in the murine inner ear [ Bone, 2021, 145:115837] | PubMed: 33385614 |
| Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1 [ Mol Oncol, 2020, 14(12):3153-3168] | PubMed: 33037696 |
| Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1 [ Mol Oncol, 2020, 14(12):3153-3168] | PubMed: 33037696 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.