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Technical Data
| Formula | C20H20N2O4 |
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| Molecular Weight | 352.38 | CAS No. | 1431985-92-0 | |
| Solubility (25°C)* | In vitro | DMSO | 70 mg/mL (198.64 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. | ||||||||
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| Targets |
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| In vitro | K02288 dose-dependently inhibits BMP4- and BMP6- induced Smad1/5/8 phosphorylation in C2C12 cells without affecting TGF-β-BMP signaling. [1] | ||||||||
| In vivo | In Zebrafish Embryos, K02288 induces a dorsalized phenotype in a dose dependent manner without effect om intersomitic vessel (ISV) formation. [1] | ||||||||
| Features | A chemical probe for BMP signaling in cells. |
Protocol (from reference)
| Animal Study: |
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Customer Product Validation
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, , Cancer Invest, 2017, 35(9):601-609
Selleck's K02288 has been cited by 24 publications
| Defects of the spliceosomal gene SNRPB affect osteo- and chondro-differentiation [ FEBS J, 2024, 291(2):272-291] | PubMed: 37584444 |
| Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma [ J Neurooncol, 2024, 10.1007/s11060-024-04625-2] | PubMed: 38446374 |
| Signal requirement for cortical potential of transplantable human neuroepithelial stem cells [ Nat Commun, 2022, 13(1):2844] | PubMed: 35606347 |
| BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma [ Int J Mol Sci, 2022, 23(3)1475] | PubMed: 35163396 |
| Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding [ Int J Mol Sci, 2022, 23(15)8147] | PubMed: 35897723 |
| Electrochemically induced in vitro focal hypoxia in human neurons [ Front Cell Dev Biol, 2022, 10:968341] | PubMed: 36247014 |
| Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] | PubMed: 34997030 |
| Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils [ Nat Commun, 2021, 12(1):6177] | PubMed: 34702814 |
| BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma [ Mol Oncol, 2021, 10.1002/1878-0261.12963] | PubMed: 33834612 |
| Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration [ Int J Mol Sci, 2021, 22(8)3945] | PubMed: 33920448 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.