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Technical Data
| Formula | C15H17ClIN3O3 |
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| Molecular Weight | 449.67 | CAS No. | 1469337-95-8 | |
| Solubility (25°C)* | In vitro | 0.5MNAOH | 3 mg/mL (6.67 mM) | |
| DMSO | 0.01 mg/mL (0.02 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). | |
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| In vitro | K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1] |
Protocol (from reference)
Customer Product Validation
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Data from [Data independently produced by , , Oncotarget, 2016, 7(9):10064-72]
Selleck's K-Ras(G12C) inhibitor 12 has been cited by 3 publications
| High-Content and High-Throughput Clonogenic Survival Assay Using Fluorescence Barcoding [ Cancers -Basel), 2023, 15(19)4772] | PubMed: 37835466 |
| An In Vivo Inflammatory Loop Potentiates KRAS Blockade [ Biomedicines, 2022, 10(3)592] | PubMed: 35327394 |
| Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression. [Wang Q, et al. Oncotarget, 2016, 7(9):10064-72] | PubMed: 26848526 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.