JNK Inhibitor IX

Catalog No.S7508 Batch:S750801

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Technical Data

Formula

C20 H16 N2 O S
Molecular Weight 332.42 CAS No. 312917-14-9
Solubility (25°C)* In vitro DMSO 20 mg/mL (60.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
1.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description JNK inhibitor IX (TCS JNK 5a) is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.
Targets
JNK3 [1] JNK2 [1]
6.7(pIC50) 6.5(pIC50)
In vitro JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. [2] JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues. [3]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Tumor Biol, 2016, 37:3135–3144.]

Selleck's JNK Inhibitor IX has been cited by 9 publications

A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome [ Cell Mol Immunol, 2023, 20(8):908-923] PubMed: 37308559
Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner [ Nat Commun, 2023, 14(1):3364] PubMed: 37291128
Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance. [ Nat Commun, 2020, 11(1):258] PubMed: 31937753
Targeting JNK pathway promotes human hematopoietic stem cell expansion. [ Cell Discov, 2019, 5:2] PubMed: 30622738
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length. [ Elife, 2018, 7] PubMed: 29595474
Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway [ Front Immunol, 2017, 8:2011] PubMed: 29403485
Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells. [Zhou C, et al. Tumour Biol, 2016, 37(3):3135-44] PubMed: 26427664
Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. [ Stem Cell Reports, 2015, 4(3):489-502] PubMed: 25684228
ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration [ PLoS Genet, 2015, 11(10):e1005595] PubMed: 26496642

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.