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Formula | C20H23BCl2N2O9 |
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Molecular Weight | 517.12 | CAS No. | 1239908-20-3 | ||||||||
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (193.37 mM) | ||||||||
Ethanol | 25 mg/mL (48.34 mM) | ||||||||||
Water | Insoluble | ||||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Ixazomib Citrate (MLN9708) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively. | ||||||||
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Targets |
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Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors [ J Exp Clin Cancer Res, 2022, 41(1):249] | PubMed: 35971164 |
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma [ Cell Death Dis, 2022, 13(3):197] | PubMed: 35236820 |
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975] | PubMed: 36313330 |
Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression [ Clin Cancer Res, 2021, 27(5):1410-1420] | PubMed: 33310890 |
Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer [ Oncogene, 2019, 38(16):3047-3060] | PubMed: 30617306 |
The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2 [ Mol Cancer Res, 2019, 17(12):2444-2456] | PubMed: 31540997 |
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers [ Proc Natl Acad Sci U S A, 2017, 114(2):382-387] | PubMed: 28028240 |
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma [ Mol Cancer Ther, 2017, 16(11):2375-2386] | PubMed: 28878026 |
Identification of the anticancer effects of a novel proteasome inhibitor, ixazomib, on colorectal cancer using a combined method of microarray and bioinformatics analysis [ Onco Targets Ther, 2017, 10:3591-3606] | PubMed: 28790851 |
Ixazomib enhances parathyroid hormone-induced β-catenin/T-cell factor signaling by dissociating β-catenin from the parathyroid hormone receptor [ Mol Biol Cell, 2017, 28(13):1792-1803] | PubMed: 28495797 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.