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Technical Data
| Formula | C10H10O4 |
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| Molecular Weight | 194.18 | CAS No. | 537-73-5 | |
| Solubility (25°C)* | In vitro | DMSO | 38 mg/mL (195.69 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. |
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| In vitro | Isoferulic acid can activate the α1A-AR to enhance glucose uptake into C2C12 cells[1]. Isoferulic acid is a potent inhibitors against intestinal maltase with an IC50 of 0.76±0.03 mM and it is also an intestinal sucrase inhibitor with IC50 of 0.45±0.01 mM. It activates α1-adrenoceptors to enhance the secretion of β-endorphin, which stimulates the opioid μ-receptors to increase glucose use and/or reduce hepatic gluconeogenesis, resulting in a reduction of the plasma glucose concentration[3]. |
| In vivo | Isoferulic acid increases the glucose utilization in skeletal muscle and reduces the hepatic gluconeogenesis in insulin-deficient rat[1]. Isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin[2]. |
Protocol (from reference)
| Animal Study:[2] |
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References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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