ISCK03

Catalog No.S2070 Batch:S207001

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Technical Data

Formula

C19H21N3O2S

 

Molecular Weight 355.45 CAS No. 945526-43-2
Solubility (25°C)* In vitro DMSO 71 mg/mL (199.74 mM)
Ethanol 3 mg/mL (8.44 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide) is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.
Targets
SCF [1] c-Kit [1]

Protocol (from reference)

Selleck's ISCK03 has been cited by 4 publications

Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1+ CD8+ T cells in HCC via blocking VEGFR2 [ Cancer Sci, 2023, 114(4):1284-1296] PubMed: 36609997
Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1+ CD8+ T cells in HCC via blocking VEGFR2 [ Cancer Sci, 2023, 114(4):1284-1296] PubMed: 36609997
Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1+ CD8+ T cells in HCC via blocking VEGFR2 [ Cancer Sci, 2023, 114(4):1284-1296] PubMed: 36609997
Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathway [ Front Pharmacol, 2022, 13:932092] PubMed: 36003494

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.