Iron sucrose

Catalog No.S3729 Batch:S372901

Technical Data

Formula	C₁₈H₂₄Fe₂O₂₄
Molecular Weight	736.06	CAS No.	8047-67-4
Solubility (25°C)*	In vitro	DMSO	100 mg/mL (135.85 mM)
		Water	100 mg/mL (135.85 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.
In vitro	Iron sucrose (0.01 mg/mL) used as an additive to culture medium for 24 h was cytotoxic to human peritoneal mesothelial cells in in vitro culture as reflected by its effect on the cells' growth, viability and synthesis of IL-6; all these effects were dosedependent. At higher, concentrations cytotoxic effects of iron sucrose appeared. Toxic effect of iron towards the mesothelial cells may be linked to increased production of free radicals. Iron sucrose enters into the cytosol of the mesothelial cells, where it is probably transported in a process of endocytosis^[1].

Description

Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.

In vitro

Iron sucrose (0.01 mg/mL) used as an additive to culture medium for 24 h was cytotoxic to human peritoneal mesothelial cells in in vitro culture as reflected by its effect on the cells' growth, viability and synthesis of IL-6; all these effects were dosedependent. At higher, concentrations cytotoxic effects of iron sucrose appeared. Toxic effect of iron towards the mesothelial cells may be linked to increased production of free radicals. Iron sucrose enters into the cytosol of the mesothelial cells, where it is probably transported in a process of endocytosis^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines human peritoneal mesothelial cells. Concentrations 0.01 mg/mL Incubation Time 24 h Method --

References

[1] Breborowicz M, et al. Eur J Clin Invest. 2003, 33(12):1038-44.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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