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Technical Data
| Formula | C21H22N4O2 |
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| Molecular Weight | 362.42 | CAS No. | 331001-62-8 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (198.66 mM) | |
| Ethanol | 7 mg/mL (19.31 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction. | |
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| In vivo | IQ1 decreases the size of the lung and dramatically decreased the number of branching tips. Despite the branching inhibition at the distal tips, IQ1 causes an elongation of the proximal airway compared to the control lung at E14.5. This elongation of the proximal airways suggests that the impact of IQ1 is not due simply to growth inhibition. IQ1 also inhibits branching with 3 day treatment initiating at E9.9; IQ1 causes airway dilation and decreased the density of mesenchymal cells. IQ1 also affects cardiac and vascular system development. IQ1 decreases the expression of distal genes and increased the expression of proximal genes in the lung explants consistent with the hypothesis that inhibition of the β-catenin/p300 interaction proximalizes lung epithelium[2]. |
Protocol (from reference)
| Animal Study:[2] |
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References
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Selleck's IQ-1 has been cited by 4 publications
| Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300 [ Haematologica, 2022, 10.3324/haematol.2022.280760] | PubMed: 35950533 |
| CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2 [ Neoplasia, 2020, 23(1):1-11] | PubMed: 33190089 |
| A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. [ Cell Mol Life Sci, 2019, 76(14):2817-2832] | PubMed: 30887098 |
| A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis [ Front Genet, 2018, 9:746] | PubMed: 30728831 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.