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Formula | C22H20FN3O2 |
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Molecular Weight | 377.41 | CAS No. | 1129669-05-1 | |
Solubility (25°C)* | In vitro | DMSO | 75 mg/mL (198.72 mM) | |
Ethanol | 10 mg/mL (26.49 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. | ||
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In vitro | In hNPCs, IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly. Through the activation of canonical Wnt signalling pathway, IM-12 promotes the neuronal differentiation of human neural progenitor cells. [1] |
Kinase Assay:[1] |
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Cell Assay:[1] |
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Data from [Data independently produced by , , Exp Cell Res, 2016, 345(2):206-17.]
Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously [ Nat Commun, 2024, 15(1):668] | PubMed: 38253551 |
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation [ Cell Stem Cell, 2023, 30(9):1235-1245.e6] | PubMed: 37683604 |
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region [ Cell Rep, 2022, 38(9):110457] | PubMed: 35235780 |
Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] | PubMed: 34997030 |
B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency [ Proc Natl Acad Sci U S A, 2020, 117(44):27435-27444] | PubMed: 33087559 |
A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application [ Carcinogenesis, 2020, 41(7):993-1004] | PubMed: 31740922 |
RHAMM inhibits cell migration via the AKT/GSK3β/Snail axis in luminal A subtype breast cancer [ Anat Rec (Hoboken), 2020, 303(9):2344-2356] | PubMed: 31769593 |
Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling. [ Sci Rep, 2019, 9(1):4739] | PubMed: 30894622 |
Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway. [ Oncol Rep, 2019, 41(6):3281-3291] | PubMed: 31002361 |
IM-12 activates the Wnt-β-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke. [ Biochem Cell Biol, 2019, 97(6):702-708] | PubMed: 31770017 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.