Icatibant Acetate

Catalog No.S5695 Batch:S569502

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Technical Data

Formula

C61H93N19O15S
Molecular Weight 1364.57 CAS No. 138614-30-9
Solubility (25°C)* In vitro DMSO 100 mg/mL (73.28 mM)
Water 100 mg/mL (73.28 mM)
Ethanol 100 mg/mL (73.28 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
2.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.
Targets
bradykinin B2 receptor [1]
In vitro

Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, resulting in a longer half-life than bradykinin which it antagonizes[1].
In vivo

Icatibant exhibits efficacy in bradykinin-mediated angioedema attacks, and induces rapid symptom relief[1].

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.