Hyoscyamine

Catalog No.S4014 Batch:S401401

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Technical Data

Formula

C17H23NO3
Molecular Weight 289.37 CAS No. 101-31-5
Solubility (25°C)* In vitro DMSO 58 mg/mL (200.43 mM)
Ethanol 58 mg/mL (200.43 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
30%propylene glycol 5%Tween80 65%D5W
5.0mg/ml Taking the 1 mL working solution as an example, add 300 μL of clarified propylene glycol stock solution of 16.67 mg/ml to 50 μL of Tween 80, mix evenly to clarify it; then continue to add 650 μL of D5W to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.
Targets
AChR [1]
7.5 nM
In vitro L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. [2] R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. [3] Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. [4] S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. [5]
In vivo L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. [6]
Features R-(+)-hyoscyamine is 30-fold lower in potency than that of the S-(-) enantiomer.

Protocol (from reference)

Animal Study:[6]
  • Animal Models

    Rats

  • Dosages

    20 mg/kg

  • Administration

    Intravenous injection

Selleck's Hyoscyamine has been cited by 1 publication

Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy [ Theranostics, 2022, 12(12):5488-5503] PubMed: 35910792

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.