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Technical Data
| Formula | -- |
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| Molecular Weight | CAS No. | 9050-30-0 | ||
| Solubility (25°C)* | In vitro | Water | 100 mg/mL | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury. | ||
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Protocol (from reference)
References
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Selleck's Heparan Sulfate has been cited by 8 publications
| A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans [ bioRxiv, 2024, 2024.05.23.595417] | PubMed: 38826446 |
| Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier [ Mol Genet Genomics, 2022, 297(2):397-405] | PubMed: 35103870 |
| Phenotypic spectrum of FGF10-related disorders: a systematic review [ PeerJ, 2022, 10:e14003] | PubMed: 36124135 |
| Specificity and action pattern of heparanase Bp, a β-glucuronidase from Burkholderia pseudomallei [ Glycobiology, 2019, 29-8:572-581] | PubMed: 31143933 |
| Contrasting transcriptome landscapes of rabbit pluripotent stem cells in vitro and in vivo [ Anim Reprod Sci, 2014, 149(1-2):67-79] | PubMed: 25059199 |
| Towards GAG glycomics: analysis of highly sulfated heparins by MALDI-TOF mass spectrometry [ Glycobiology, 2007, 17(9):972-82] | PubMed: 17623722 |
| KATAMARI1/MURUS3 Is a novel golgi membrane protein that is required for endomembrane organization in Arabidopsis [ Plant Cell, 2005, 17(6):1764-76] | PubMed: 15863516 |
| The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis [ EMBO Rep, 2000, 1(3):282-6] | PubMed: 11256613 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.