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Technical Data
| Formula | C26H28F3N3O2 |
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| Molecular Weight | 471.51 | CAS No. | 883031-03-6 | |
| Solubility (25°C)* | In vitro | DMSO | 94 mg/mL (199.35 mM) | |
| Ethanol | 24 mg/mL (50.9 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively. | ||||||
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| In vivo | HC-067047 causes a significant increase in functional bladder capacity in mice and rats suffering from cystitis, thus providing proof of principle that pharmacological inhibition of TRPV4 can be used to treat bladder dysfunction.HC-067047 had no effect on the cystometric parameters of Trpv4−/− mice demonstrates that the observed in vivo effects are specific.[1] |
Protocol (from reference)
Selleck's HC-067047 has been cited by 3 publications
| Role of Piezo2 in Schwann Cell Volume Regulation and Its Impact on Neurotrophic Release Regulation [ Cell Physiol Biochem, 2024, 58(4):292-310] | PubMed: 38973197 |
| Patch clamp studies on TRPV4-dependent hemichannel activation in lens epithelium [ Front Pharmacol, 2023, 14:1101498] | PubMed: 36909173 |
| Calcium and TRPV4 promote metastasis by regulating cytoskeleton through the RhoA/ROCK1 pathway in endometrial cancer [ Cell Death Dis, 2020, 11(11):1009] | PubMed: 33230171 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.