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Technical Data
| Formula | C28H37NO9 |
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| Molecular Weight | 531.59 | CAS No. | 26833-85-2 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (188.11 mM) | |
| Ethanol | 100 mg/mL (188.11 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
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| In vitro | Harringtonine, a cephalotaxine alkaloid, inhibits an early stage of the chikungunya virus (CHIKV) replication cycle which occurs after viral entry into cells and affects CHIKV RNA production as well as viral protein expression, also inhibits other alphaviruses.<sup><a class="sref"href="#s_ref">[1]</a></sup> |
Protocol (from reference)
Selleck's Harringtonine has been cited by 3 publications
| Translational specialization in pluripotency by RBPMS poises future lineage-decisions [ BioRxiv, 2022, 10.1101/2021.04.12.439420] | PubMed: none |
| A specialized mRNA translation circuit instated in pluripotency presets the competence for cardiogenesis in humans [ BioRxiv, 2021, PPR: PPR311141] | PubMed: none |
| The Gelation of CAG Repeat Expansion RNAs Suppresses Global Protein Translation [ Research Square, 2021, 10.21203/rs.3.rs-541829/v1] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.