GW441756

Catalog No.S2891 Batch:S289102

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Technical Data

Formula

C17H13N3O
Molecular Weight 275.3 CAS No. 504433-23-2
Solubility (25°C)* In vitro DMSO 27.5 mg/mL (99.89 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.6mg/ml Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
10%DMSO 40%PEG300 5%Tween80 45%ddH2O
0.67mg/ml Taking the 1 mL working solution as an example, add 100 μL 6.67 mg/ml clear DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 450 μL ddH2O to make it clear. Volume up to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
13.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 260 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.
Targets
TrkA [1]
(Cell-free assay)
2 nM
In vitro

GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production[2]and apoptosis in TrkA-overexpressing cells. [3]

Protocol (from reference)

Animal Study:

[4]
  • Animal Models

    Wistar male rats

  • Dosages

    10 mg/kg

  • Administration

    i.p.

Customer Product Validation

Data from [Data independently produced by , , Exp Neurol, 2018, 300:87-99]

Data from [Data independently produced by , , Mol Cell Neurosci, 2016, 77:11-20.]

Data from [Data independently produced by , , Int J Mol Med, 2018, 42(3):1484-1494]

Selleck's GW441756 has been cited by 19 publications

Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA [ Cells, 2023, 12(3)373] PubMed: 36766714
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA. Cells 2023, 12, 373 [ Cells, 2023, 12(3):373] PubMed: None
The effect of Banxia-houpo decoction on CUMS-induced depression by promoting M2 microglia polarization via TrkA/Akt signalling [ J Cell Mol Med, 2023, 10.1111/jcmm.17906] PubMed: 37581474
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] PubMed: 37609072
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] PubMed: 37609072
Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs [ Mediators Inflamm, 2023, 2023:4436587] PubMed: 36860203
Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway [ Microbes Infect, 2022, S1286-4579(22)00050-8] PubMed: 35430372
Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [ Biosci Biotechnol Biochem, 2021, 85(3):675-686] PubMed: 33589896
Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. [ Theranostics, 2020, 10(4):1649-1677] PubMed: 32042328
Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors [ Cancer Res, 2020, canres.1992.2020] PubMed: 33203698

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Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.