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Technical Data
| Formula | C21H28O2 |
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| Molecular Weight | 312.45 | CAS No. | 95975-55-6 | |
| Solubility (25°C)* | In vitro | DMSO | 21 mg/mL warmed with 50ºC water bath (67.21 mM) | |
| Ethanol | 5 mg/mL (16.0 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity. |
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Protocol (from reference)
Selleck's Guggulsterone E&Z has been cited by 6 publications
| Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway [ Gut Microbes, 2024, 16(1):2379566] | PubMed: 39013030 |
| Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis [ Nat Commun, 2023, 14(1):6908] | PubMed: 37903763 |
| Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis [ Nat Commun, 2023, 14(1):6908] | PubMed: 37903763 |
| Intrahepatic Cholestasis of Pregnancy Increases Inflammatory Susceptibility in Neonatal Offspring by Modulating Gut Microbiota [ Front Immunol, 2022, 13:889646] | PubMed: 35769469 |
| Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. [ Int J Oncol, 2019, 54(3):879-892] | PubMed: 30747230 |
| Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. [ Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(10):1293-1304] | PubMed: 31170503 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.