Guggulsterone E&Z

Catalog No.S3792 Batch:S379201

Technical Data

Formula

C₂₁H₂₈O₂

Molecular Weight

312.45

CAS No.

95975-55-6

Solubility (25°C)*

In vitro

DMSO (warmed with 50ºC water bath)

35 mg/mL (112.01 mM)

In vivo (Add solvents to the product individually and in order)

Clear solution

5%DMSO 1 Corn oil

0.25mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.

Protocol (from reference)

Selleck's Guggulsterone E&Z has been cited by 6 publications

Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway [ Gut Microbes, 2024, 16(1):2379566]	PubMed: 39013030
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis [ Nat Commun, 2023, 14(1):6908]	PubMed: 37903763
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis [ Nat Commun, 2023, 14(1):6908]	PubMed: 37903763
Intrahepatic Cholestasis of Pregnancy Increases Inflammatory Susceptibility in Neonatal Offspring by Modulating Gut Microbiota [ Front Immunol, 2022, 13:889646]	PubMed: 35769469
Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. [ Int J Oncol, 2019, 54(3):879-892]	PubMed: 30747230
Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. [ Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(10):1293-1304]	PubMed: 31170503

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.