GlyH-101

Catalog No.S8094 Batch:S809401

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Technical Data

Formula

C19H15Br2N3O3

Molecular Weight 493.15 CAS No. 328541-79-3
Solubility (25°C)* In vitro DMSO 98 mg/mL (198.72 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.
Targets
CFTR [1]
4.3 μM(Ki)
In vitro GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]
In vivo In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    CD1 mice

  • Dosages

    10 μM

  • Administration

    Topical treatment

Selleck's GlyH-101 has been cited by 3 publications

The cystic fibrosis treatment Trikafta affects the growth, viability, and cell wall of Aspergillus fumigatus biofilms [ mBio, 2023, 14(5):e0151623] PubMed: 37830825
The cystic fibrosis treatment Trikafta affects the growth, viability, and cell wall of Aspergillus fumigatus biofilms [ mBio, 2023, 14(5):e0151623] PubMed: 37830825
CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity [ Cell Mol Immunol, 2020, 10.1038/s41423-020-0499-3] PubMed: 32669666

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.