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Formula | C20H20O4 |
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Molecular Weight | 324.37 | CAS No. | 59870-68-7 | |
Solubility (25°C)* | In vitro | DMSO | 64 mg/mL (197.3 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. | ||||||||||
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In vitro | Glabridin induces dose-dependent increase in estrogenic activity and cell proliferation in Ishikawa cells. Glabridin exerts estrogenic activity via the ER-α-SRC-1-co-activator complex[1]. Glabridin has substantial neuroprotective effects, as indicated by the reduced cell death, apoptosis, DNA fragmentation, probably through the regulation of bcl-2, Bax and caspase-3 which are all closely related to cell apoptotic process[2]. | ||||||||||
In vivo | Glabridin at 25mg/kg by intraperitoneal injection, but not at 5mg/kg, significantly decreases the focal infarct volume, cerebral histological damage and apoptosis in MCAO rats compared to sham-operated rats. Glabridin significantly attenuates the level of brain malonyldialdehyde (MDA) in MCAO rats, while it elevates the level of two endogenous antioxidants in the brain, i.e. superoxide dismutase (SOD) and reduced glutathione (GSH). Co-treatment with glabridin significantly inhibits the staurosporine-induced cytotoxicity and apoptosis of cultured rat cortical neurons in a concentration-dependent manner. Consistently, glabridin significantly reduces the DNA laddering caused by staurosporine in a concentration-dependent manner. Glabridin has a neuroprotective effect via modulation of multiple pathways associated with apoptosis. Glabridin appears to achieve steady state concentrations slowly in humans. The limited penetration of glabridin into the brain due to the activity of P-glycoprotein in the blood-brain barrier may also lessen the activity of glabridin at low doses[2]. |
Cell Assay:[1] |
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Animal Study:[2] |
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Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy [ Life Sci, 2021, S0024-3205(20)31752-5] | PubMed: 33417956 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.