Gibberellic acid

Catalog No.S4766 Batch:S476601

Technical Data

Formula	C₁₉H₂₂O₆
Molecular Weight	346.37	CAS No.	77-06-5
Solubility (25°C)*	In vitro	DMSO	69 mg/mL (199.2 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.
In vivo	Gibberellic acid (GA3) acts as an agonist of steroidogenesis in male rats. Administration of GA3 to rat causes reduction in liver carbohydrates, total protein content, serum levels of aspartate and alanine amino transferases and alkaline phosphatase in a time- and dose- dependent mannner. It is reported that GA3 causes hepatonephrotoxicity, oxidative stress and DNA damage in rat testis. Abscisic acid and GA3 have been found to affect sexual differentiation and other physiological characteristics in mice^[1]. Gibberellic acid is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally^[2].

Description

Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.

In vivo

Gibberellic acid (GA3) acts as an agonist of steroidogenesis in male rats. Administration of GA3 to rat causes reduction in liver carbohydrates, total protein content, serum levels of aspartate and alanine amino transferases and alkaline phosphatase in a time- and dose- dependent mannner. It is reported that GA3 causes hepatonephrotoxicity, oxidative stress and DNA damage in rat testis. Abscisic acid and GA3 have been found to affect sexual differentiation and other physiological characteristics in mice^[1]. Gibberellic acid is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally^[2].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models normal and diabetic Wistar male rats Dosages 150 μg/day Administration Oral administration

References

[1] Premalatha R, et al. Andrologia. 2014, 46(8):902-9.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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