Flavone

Catalog No.S3967 Batch:S396701

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Technical Data

Formula

C15H10O2
Molecular Weight 222.24 CAS No. 525-82-6
Solubility (25°C)* In vitro DMSO 44 mg/mL (197.98 mM)
 
 
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.2mg/ml Taking the 1 mL working solution as an example, add 50 μL of 44 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
In vitro Flavone is found to reduce cell proliferation in HT-29 cells with an EC50 value of 54.8 ± 1.3 μm and to potently induce differentiation as well as apoptosis. The effects of flavone in HT-29 cells are associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor κB (NF-κB), and bcl-XL. Moreover, flavone displays a high selectivity for the induction of apoptosis and of growth inhibition only in the transformed colonocytes[1].
In vivo In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice. Apoptotic cells and an increase in p21, but not p53, protein are observed in tumor tissues derived from flavone-treated group. Flavone has been shown to accumulate in intestinal cells suggesting the potential application of flavone in treatment of colorectal carcinoma[2].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HT-29 Cells

  • Concentrations

    1-1000 μM

  • Incubation Time

    72 h

  • Method

    Cells (5 × 103 per well) are incubated for 72 h with medium alone (control) or containing the compounds at various concentrations and cell numbers are determined subsequently using SYTOX-Green nucleic acid stain.
Animal Study:

[2]
  • Animal Models

    Male BALB/c nu/nu mice (Tumor-bearing mice injected COLO205 cells s.c.)

  • Dosages

    10 and 20 mg/kg

  • Administration

    i.p.

Selleck's Flavone has been cited by 1 publication

RORγ Is a Targetable Master Regulator of Cholesterol Biosynthesis in a Cancer Subtype [ Nat Commun, 2019, 11;10(1):4621] PubMed: 31604910

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.