Finerenone

Catalog No.S9702 Batch:S970201

Technical Data

Formula	C₂₁H₂₂N₄O₃
Molecular Weight	378.42	CAS No.	1050477-31-0
Solubility (25°C)*	In vitro	DMSO	76 mg/mL (200.83 mM)
		Ethanol	10 mg/mL (26.42 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

Targets

MR ^[1]
(Cell-free assay)

18 nM

In vitro

In vitro, Finerenone dose-dependently reduces aldosterone-induced smooth muscle cell (SMC) proliferation and prevents aldosteroneinduced endothelial cell (EC) apoptosis. Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels.^[2]

In vivo

Finerenone improves endothelial dysfunction through an enhancement in NO bioavailability and a decrease in superoxide anion levels due to an upregulation in SOD activity. This is associated with an increase in renal SOD activity and a reduction of albuminuria.^[1]

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines Human coronary artery smooth muscle cells (SMC), human umbilical vein endothelial cells (EC) Concentrations 1 nM, 10 nM Incubation Time 24 h Method Cells are incubated with aldosterone with or without finerenone for 24 hours after 24 hours of serum-starvation for the assessment of cell proliferation and apoptosis. Immediately prior to the addition of aldosterone, cells are preincubated with finerenone or vehicle for 30 minutes.
Animal Study:^{^[1]}	Animal Models 12-week-old MWF, aged-matched normoalbuminuric Wistar rats Dosages 10 mg/kg Administration Oral gavage

Cell Assay:^{^[2]}

Cell lines
Human coronary artery smooth muscle cells (SMC), human umbilical vein endothelial cells (EC)
Concentrations
1 nM, 10 nM
Incubation Time
24 h
Method
Cells are incubated with aldosterone with or without finerenone for 24 hours after 24 hours of serum-starvation for the assessment of cell proliferation and apoptosis. Immediately prior to the addition of aldosterone, cells are preincubated with finerenone or vehicle for 30 minutes.

Animal Study:^{^[1]}

Animal Models
12-week-old MWF, aged-matched normoalbuminuric Wistar rats
Dosages
10 mg/kg
Administration
Oral gavage

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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