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Formula | C15H22N2O2 |
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Molecular Weight | 262.35 | CAS No. | 347174-05-4 | ||||||||||||
Solubility (25°C)* | In vitro | DMSO | 52 mg/mL (198.2 mM) | ||||||||||||
Ethanol | 52 mg/mL (198.2 mM) | ||||||||||||||
Water | Insoluble | ||||||||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Fer-1 (Ferrostatin-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. | ||
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In vitro | Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions. [1] |
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In vivo | Ferrostatin-1 (Fer-1), a synthetic antioxidant, is a potent and selective inhibitor of ferroptosis. It acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death.[2] |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Hepatology, 2016, 64(2):488-500]
Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]
Data from [Data independently produced by , , Oncogene, 2015, 10.1038/onc.2015.32]
Data from [Data independently produced by , , Mol Carcinog, 2018, 57(11):1566-1576]
7-Dehydrocholesterol dictates ferroptosis sensitivity [ Nature, 2024, 626(7998):411-418.] | PubMed: 38297130 |
7-Dehydrocholesterol dictates ferroptosis sensitivity [ Nature, 2024, 626(7998):411-418.] | PubMed: 38297130 |
Characterization of ferroptosis-triggered pyroptotic signaling in heart failure [ Signal Transduct Target Ther, 2024, 9(1):257] | PubMed: 39327446 |
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis [ Mol Cancer, 2024, 23(1):113] | PubMed: 38802795 |
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury [ Cell Metab, 2024, S1550-4131(24)00371-1] | PubMed: 39389061 |
Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH [ Cell Metab, 2024, S1550-4131(24)00284-5] | PubMed: 39142286 |
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma [ J Hematol Oncol, 2024, 17(1):78] | PubMed: 39218945 |
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments [ Nat Cell Biol, 2024, 26(5):825-838] | PubMed: 38605144 |
Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction [ Nat Commun, 2024, 15(1):8971] | PubMed: 39420002 |
SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis [ Nat Commun, 2024, 15(1):7522] | PubMed: 39215042 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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