Farrerol

Catalog No.S9552 Batch:S955203

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Technical Data

Formula

C17H16O5
Molecular Weight 300.31 CAS No. 24211-30-1
Solubility (25°C)* In vitro DMSO 60 mg/mL (199.79 mM)
Ethanol 60 mg/mL (199.79 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.
In vitro

Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation.[1]
In vivo

In 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model, Farrerol has a protective effect on TNBS-induced colitis. Farrerol administration significantly improves the weight change, clinical scores, colon length, and intestinal epithelium barrier damage and markedly decreases the production of the inflammatory cytokines in TNBS-induced mice. [1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    RAW264.7 cells

  • Concentrations

    25 μM-200 μM

  • Incubation Time

    1 h

  • Method

    RAW264.7 cells are pretreated with Farrerol for 1 h and then stimulated with LPS (1 μg/mL). RAW264.7 cells or the culture medium are collected and used to measure the reflections of pro-inflammatory mediators and the phosphorylation of signaling pathway by quantitative real-time PCR- and ELISA-analysis, respectively.

Selleck's Farrerol has been cited by 3 publications

Antioxidant, Anti-Apoptotic, and Anti-Inflammatory Effects of Farrerol in a Mouse Model of Obstructive Uropathy [ Curr Issues Mol Biol, 2023, 45(1):337-352] PubMed: 36661510
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro [ Front Pharmacol, 2022, 13:1079251] PubMed: 36686707
Farrerol exhibits inhibitory effects on lung adenocarcinoma cells by activating the mitochondrial apoptotic pathway [ J Biochem Mol Toxicol, 2022, 36(10):e23157] PubMed: 35833306

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.