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Technical Data
| Formula | C24H22FN3O4.CH4O3S |
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| Molecular Weight | 531.55 | CAS No. | 169869-90-3 | |
| Solubility (25°C)* | In vitro | DMSO | 12.5 mg/mL (23.51 mM) | |
| Water | 12.5 mg/mL (23.51 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Exatecan Mesylate (DX-8951f) is a water-soluble and non-pro-drug analog of camptothecin and shows significant topoisomerase I inhibition with IC50 of 0.975 μg/ml. | ||
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| Targets |
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| In vitro | Exatecan Mesylate shows both high potency against a series of 32 malignant cell lines and significant topoisomerase I inhibition in vitro. The anti‐proliferative activity of Exatecan Mesylate is about 6 and 28 times greater than that of SN‐38 or SK&F 10486‐A, respectively.[1] |
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| In vivo | In mice, the antitumor activity of three doses of Exatecan Mesylate administered i.v. at 4‐day intervals against human gastric adenocarcinoma SC‐6 xenografts is greater than that of CPT‐11 or SK&F 10486‐A. Moreover, it overcame P‐glycoprotein‐mediated multi‐drug resistance. These data suggest that Exatecan Mesylate has a high antitumor activity and is a potential therapeutic agent.[1] |
Protocol (from reference)
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.