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Formula | C30H31ClN4O4 |
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Molecular Weight | 547.04 | CAS No. | 571203-78-6 | |
Solubility (25°C)* | In vitro | DMSO | 33 mg/mL (60.32 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared. | |
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In vitro | Erastin is selectively lethal to oncogenic RAS-mutant cell lines, and triggers a unique iron-dependent form of non-apoptotic cell death called ferroptosis. [1] [2] Erastin binds directly to VDAC2 and causes mitochondrial damage via ROS production in an NADH-dependent manner, which induces cell death in some tumor cells harbouring activating mutations in the RAS-RAF-MEK pathway. [3] In addition, erastin, via inducing ROS-mediated CID (Caspase-independent cell death), strongly enhances the effect in WT EGFR cells. [4] |
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In vivo | Erastin is a ferroptosis activator by inhibiting voltage-dependent anion channels (VDAC2/VDAC3). It also inhibits cystine-glutamate antiporter (xCT).[5] |
Cell Assay: |
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Animal Study:
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, , Cancer Res, 2017, 77(8):2064-2077
Data from [Data independently produced by , , Gastroenterology, 2017, 153(5):1429-1443]
Data from [Data independently produced by , , Gastroenterology, 2018, 154(5):1480-1493]
Data from [Data independently produced by , , Hepatology, 2016, 64(2):488-500.]
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury [ Cell Metab, 2024, S1550-4131(24)00371-1] | PubMed: 39389061 |
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence [ Nat Commun, 2024, 15(1):1429] | PubMed: 38365899 |
SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis [ Nat Commun, 2024, 15(1):7522] | PubMed: 39215042 |
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis [ Nat Commun, 2024, 15(1):4114] | PubMed: 38750057 |
FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy [ Adv Sci (Weinh), 2024, 11(40):e2402671] | PubMed: 39206719 |
A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma [ Cell Death Differ, 2024, 10.1038/s41418-024-01324-3] | PubMed: 38862581 |
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis [ Theranostics, 2024, 14(10):4090-4106] | PubMed: 38994016 |
HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells [ Genome Biol, 2024, 25(1):58] | PubMed: 38409044 |
LACTB suppresses liver cancer progression through regulation of ferroptosis [ Redox Biol, 2024, 75:103270] | PubMed: 39047638 |
Cold atmospheric plasma enhances SLC7A11-mediated ferroptosis in non-small cell lung cancer by regulating PCAF mediated HOXB9 acetylation [ Redox Biol, 2024, 75:103299] | PubMed: 39127016 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.