Entacapone

Catalog No.S3147 Batch:S314701

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Technical Data

Formula

C14H15N3O5
Molecular Weight 305.29 CAS No. 130929-57-6
Solubility (25°C)* In vitro DMSO 61 mg/mL (199.81 mM)
Ethanol 2 mg/mL (6.55 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.
Targets
COMT [1]
151 nM
In vitro

Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. [1]

Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. [2]
In vivo

Entacapone administration reduced body weight and lowered fasting blood glucose concentrations in diet-induced obese mice.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    PC12 cells

  • Concentrations

    5 μM

  • Incubation Time

    72 h

  • Method

    Cells were treated with various concentrations of drug for 72 h.
Animal Study:

[5]
  • Animal Models

    Male C57BL/6 mice

  • Dosages

    600 mg/kg

  • Administration

    p.o.

Selleck's Entacapone has been cited by 2 publications

Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum [ Elife, 2022, 11e72668] PubMed: 35018884
Glucose-sensing in AgRP neurons integrates homeostatic energy state with dopamine signalling in the striatum [ bioRxiv, 2021, 10.1101/2021.03.22.436393] PubMed: None

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.