Emb01 (Anti-cMet & EGFR)

Catalog No.A4032

Technical Data

CAS No.	2437210-79-0
Source	CHO
Storage (From the date of receipt)	-80℃

Biological Activity

Description	Emb01 is a tetravalent, bispecific antibody that simultaneously targets the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (cMET) on tumor cells, preventing receptor activation and inducing receptor endocytosis, which effectively eliminates these targets on tumor cell surfaces. It demonstrates significant anti-tumor activity in patient-derived xenograft (PDX) and cell line-derived xenograft (CDX) models, with the potential to treat EGFR antibody-resistant non-small cell lung cancer (NSCLC). MW: 237.9 KD.

Description

Emb01 is a tetravalent, bispecific antibody that simultaneously targets the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (cMET) on tumor cells, preventing receptor activation and inducing receptor endocytosis, which effectively eliminates these targets on tumor cell surfaces. It demonstrates significant anti-tumor activity in patient-derived xenograft (PDX) and cell line-derived xenograft (CDX) models, with the potential to treat EGFR antibody-resistant non-small cell lung cancer (NSCLC). MW: 237.9 KD.

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

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