Eliglustat hemitartrate

Catalog No.S4433 Batch:S443303

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Technical Data

Formula

C50H78N4O14
Molecular Weight 959.17 CAS No. 928659-70-5
Solubility (25°C)* In vitro DMSO 100 mg/mL (104.25 mM)
Water 100 mg/mL (104.25 mM)
Ethanol 100 mg/mL (104.25 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.71mg/ml Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.
Targets
Glucosylceramide Synthase [1]
(Cell-free assay)
24 nM
In vitro

When treated gaucher disease neuronal progenitor cells (NPCs) with the GlcCer synthase inhibitors Eliglustat and the brain‐penetrant Ibiglustat, there are significant reductions in both, GlcCer and GlcSph levels in the mutant NPCs.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    gaucher disease neuronal progenitor cells

  • Concentrations

    2 μM

  • Incubation Time

    5 days

  • Method

    For GlcCer synthase inhibition, NPCs were treated with a final concentration of 2 μM Eliglustat, Ibiglustat, or GZ667161, for 5 days.

Selleck's Eliglustat hemitartrate has been cited by 2 publications

Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide [ Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(1):158817] PubMed: 32980536
Amyloid Beta-Peptide 25-35 (Aβ25-35) Induces Cytotoxicity via Multiple Mechanisms: Roles of the Inhibition of Glucosylceramide Synthase by Aβ25-35 and Its Protection by D609 [ Biol Pharm Bull, 2021, 44(10):1419-1426] PubMed: 34602551

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.