Eleutheroside B

Catalog No.S3841 Batch:S384101

Print

Technical Data

Formula

C17H24O9
Molecular Weight 372.37 CAS No. 118-34-3
Solubility (25°C)* In vitro DMSO 74 mg/mL (198.72 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
In vitro Syringin shows low cytotoxicity on the U937 and PBMC cells with IC50 of >100 and 91.14 mg/mL, respectively[1].
In vivo Syringin has a potent protection against LPS/D-GalN-induced fulminant hepatic failure (FHF), as indicated by the decreased high lethality, alleviates hepatic pathological injury, inhibits hepatocytes apoptosis and reduces hepatic inflammatory responses. Such protective effects are probably carried out through suppression of TNF-α production, which is mediated by NF-kB[2]. Syringin also protects against LPS-induced acute lung injury (ALI) by activating Nrf2 and inhibiting NF-κB signaling pathway[3]. Syringin improves glucose tolerance without increased weight gain in high-fat diet-induced obese mice. It augmentes insulin-stimulated Akt phosphorylation in skeletal muscle, epididymal adipose tissue (EAT), and the liver, showing an insulin-sensitizing activity. Syringin-treated mice also show markedly elevated adiponectin production in EAT and suppresses expression of pro-inflammatory cytokines in peripheral tissues, indicating a significant reduction in low-grade chronic inflammation. Additionally, syringin enhances AMP-activated protein kinase activity and decreases the expression of lipogenic genes in skeletal muscle, which is associated with reduced endoplasmic reticulum (ER) stress[4].

Protocol (from reference)

Animal Study:[2]
  • Animal Models

    BALB/c mice

  • Dosages

    10, 30 and 100 mg/kg

  • Administration

    i.p.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.