Edoxaban tosylate Monohydrate

Catalog No.S7280 Batch:S728001

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Technical Data

Formula

C24H30ClN7O4S.C7H8O3S.H2O
Molecular Weight 738.27 CAS No. 1229194-11-9
Solubility (25°C)* In vitro DMSO 100 mg/mL (135.45 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Targets
Factor Xa [1]
(Cell-free assay)
0.561 nM(Ki)
In vitro In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. [1]
In vivo Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. [1]

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Venous stasis thrombosis model in rats and rabbits

  • Dosages

    0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)

  • Administration

    p.o.

Selleck's Edoxaban tosylate Monohydrate has been cited by 6 publications

Unveiling the complex effects of direct oral anticoagulants on dilute Russell's viper venom time assays [ J Thromb Haemost, 2020, 18(8):1866-1873] PubMed: 32294291
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner [ Viruses, 2020, 10;12(6):E629] PubMed: 32532094
Simple LC-MS/MS method using core-shell ODS microparticles for the simultaneous quantitation of edoxaban and its major metabolites in human plasma [ J Chromatogr B Analyt Technol Biomed Life Sci, 2020, 1146:122121] PubMed: 32361632
The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro: an existing drug with multiple possible therapeutic effects [ bioRxiv, 2020, 10.1101/2020.04.22.054981] PubMed: None
Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays [ Scand J Clin Lab Invest, 2018, 78(7-8):575-583] PubMed: 30278787
Edoxaban: Impact on routine and specific coagulation assays. A practical laboratory guide [ Thromb Haemost, 2016, 115(2):368-81] PubMed: 26510969

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.