DS-1001b (DS 1001)

Catalog No.S8881 Batch:S888101

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Technical Data

Formula

C29H29Cl3FN3O4
Molecular Weight 608.92 CAS No. 1898207-64-1
Solubility (25°C)* In vitro DMSO 14 mg/mL (22.99 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier.
Targets
IDH1 R132X [1]
In vitro

DS-1001b impairs the proliferation of IDH1 mutant chondrosarcoma cell lines and decreases 2-HG levels.[2]
In vivo

Continuous administration of DS-1001b impairs tumor growth in xenograft mice.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    JJ012,L835 cell lines

  • Concentrations

    0-10µM

  • Incubation Time

    72 h

  • Method

    Cells are maintained in RPMI1640 supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin (P/S). Cells are grown at 37 °C in a humidified incubator with 95% air and 5% CO2. Then cells are treated with DS-1001b for 72 hours.

Selleck's DS-1001b (DS 1001) has been cited by 1 publication

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma [ EBioMedicine, 2024, 102:105090] PubMed: 38547578

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.